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(r = 0. 67, p < 0. 001), which impairs insulin signaling. In contrast, there was no significant association between insulin resistance and other putative lipid metabolites or plasma or hepatic markers of inflammation. Er stress markers were only partly correlated with insulin resistance. In conclusion, these data show that hepatic dag content in lipid droplets is the best predictor of insulin resistance in humans, and they support the hypothesis that nafld-associated hepatic insulin resistance is caused by an increase in hepatic dag content, which results in activation of pkcîµ. Footnotes 1to whom correspondence may be addressed. E-mail: varman. Samuel{at}yale. Edu or gerald. Shulman{at}yale. Edu. Author contributions: n. K. , k. F. P. , v. T. S. , and g. I. S. Designed research; n. K. , d. M. E. , d. Z. , m. K. , s. A. B. , x. C. , c. D. S. , g. S. G. , and x. H. Performed research; x. C. , c. D. S. , g. S. G. , x. H. , and j. D. Contributed new reagents/analytic tools; n. K. , d. M. E. , d. Z. , m. K. , s. A. B. , c. D. S. , g. S. G. , x. H. , j. D. , k. F. P. , v. T. S. , and g. I. S. Analyzed data; and n. K. , g. S. G. http://medicaresupplementspecialists.com/pfz-cheap-viagra-online-canada-pharmacy-az/ viagra online buy viagra online generic viagra online http://howtosmudge.com/pjn-viagra-buying-di/ cheap viagra online buy cheap viagra viagra for sale viagra without a doctor prescription generic viagra online , k. F. P. , v. T. S. , and g. I. S. Wrote the paper. The authors declare no conflict of interest. This article contains supporting information online at www. Pnas. Org/lookup/suppl/doi:10. 1073/pnas. 1113359108/-/dcsupplemental. Freely available online through the pnas open access option. Facebook twitter google+ citeulike connotea delicious digg mendeley what's this? â« previous | next article â» table of contents open access article this article published online before print september 19, 2011, doi: 10. 1073/pnas. 1113359108 pnas september 27, 2011 vol. 108 no. 39 16381-16385 free via open access: oa â» abstract figures only oaâ  full text full text (pdf) full text + si (combined pdf) corrected supporting information classifications biological sciences medical sciences services email this article to a colleague alert me when this article is cited alert me if a correction is posted similar articles in this journal similar articles in isi similar articles in pubmed add to my file cabinet download to citation manager request copyright permission citing articles load citing article information citing articles via crossref citing.


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